void validateClinicalAnalysisFields(ClinicalAnalysis clinicalAnalysis, Study study, String sessionId) throws CatalogException { if (clinicalAnalysis.getFamily() != null && ListUtils.isNotEmpty(clinicalAnalysis.getFamily().getMembers())) { for (Individual member : clinicalAnalysis.getFamily().getMembers()) { if (member.getId().equals(clinicalAnalysis.getProband().getId())) { proband = member; if (clinicalAnalysis.getFamily() != null && clinicalAnalysis.getFamily().getMembers() != null) { for (Individual member : clinicalAnalysis.getFamily().getMembers()) { if (member.getSamples() != null) { for (Sample sample : member.getSamples()) {
private void validateFamilyAndProband(ClinicalAnalysis clinicalAnalysis, Study study, String sessionId) throws CatalogException { if (clinicalAnalysis.getFamily() != null && StringUtils.isNotEmpty(clinicalAnalysis.getFamily().getId())) { MyResource<Family> familyResource = catalogManager.getFamilyManager().getUid(clinicalAnalysis.getFamily().getId(), study.getFqn(), sessionId); clinicalAnalysis.setFamily(familyResource.getResource()); // Check the proband is an actual member of the family Query query = new Query() .append(FamilyDBAdaptor.QueryParams.UID.key(), familyResource.getResource().getUid()) .append(FamilyDBAdaptor.QueryParams.MEMBER_UID.key(), clinicalAnalysis.getProband().getUid()); QueryResult<Family> count = catalogManager.getFamilyManager().count(study.getFqn(), query, sessionId); if (count.getNumTotalResults() == 0) { throw new CatalogException("The member " + clinicalAnalysis.getProband().getId() + " does not belong to the family " + clinicalAnalysis.getFamily().getId()); } } }
if (clinicalAnalysis.getFamily() == null || StringUtils.isEmpty(clinicalAnalysis.getFamily().getId())) { throw new AnalysisException("Missing family in clinical analysis " + clinicalAnalysisId); Pedigree pedigree = FamilyManager.getPedigreeFromFamily(clinicalAnalysis.getFamily()); OntologyTerm disease = clinicalAnalysis.getDisorder(); Phenotype phenotype = new Phenotype(disease.getId(), disease.getName(), disease.getSource(), Phenotype.Status.UNKNOWN);
@Test public void createClinicalAnalysisTest() throws CatalogException { QueryResult<ClinicalAnalysis> dummyEnvironment = createDummyEnvironment(true); assertEquals(1, dummyEnvironment.getNumResults()); assertEquals(0, dummyEnvironment.first().getInterpretations().size()); assertEquals("family", dummyEnvironment.first().getFamily().getId()); assertEquals(5, dummyEnvironment.first().getFamily().getMembers().size()); assertNotNull(dummyEnvironment.first().getProband()); assertEquals("child1", dummyEnvironment.first().getProband().getId()); assertEquals(1, dummyEnvironment.first().getProband().getSamples().size()); assertEquals("sample2", dummyEnvironment.first().getProband().getSamples().get(0).getId()); assertEquals(catalogManager.getSampleManager().getUid("sample2", STUDY, sessionIdUser).getResource().getUid(), dummyEnvironment.first().getProband().getSamples().get(0).getUid()); }
@Override public QueryResult<ClinicalAnalysis> create(String studyStr, ClinicalAnalysis clinicalAnalysis, QueryOptions options, String sessionId) throws CatalogException { String userId = catalogManager.getUserManager().getUserId(sessionId); Study study = catalogManager.getStudyManager().resolveId(studyStr, userId); authorizationManager.checkStudyPermission(study.getUid(), userId, StudyAclEntry.StudyPermissions.WRITE_CLINICAL_ANALYSIS); options = ParamUtils.defaultObject(options, QueryOptions::new); ParamUtils.checkObj(clinicalAnalysis, "clinicalAnalysis"); ParamUtils.checkAlias(clinicalAnalysis.getId(), "id"); ParamUtils.checkObj(clinicalAnalysis.getType(), "type"); ParamUtils.checkObj(clinicalAnalysis.getDueDate(), "dueDate"); if (TimeUtils.toDate(clinicalAnalysis.getDueDate()) == null) { throw new CatalogException("Unrecognised due date. Accepted format is: yyyyMMddHHmmss"); } clinicalAnalysis.setProband(getFullValidatedMember(clinicalAnalysis.getProband(), study, sessionId)); clinicalAnalysis.setFamily(getFullValidatedFamily(clinicalAnalysis.getFamily(), study, sessionId)); validateClinicalAnalysisFields(clinicalAnalysis, study, sessionId); clinicalAnalysis.setCreationDate(TimeUtils.getTime()); clinicalAnalysis.setDescription(ParamUtils.defaultString(clinicalAnalysis.getDescription(), "")); clinicalAnalysis.setStatus(new ClinicalAnalysis.ClinicalStatus()); clinicalAnalysis.setRelease(catalogManager.getStudyManager().getCurrentRelease(study, userId)); clinicalAnalysis.setAttributes(ParamUtils.defaultObject(clinicalAnalysis.getAttributes(), Collections.emptyMap())); clinicalAnalysis.setInterpretations(ParamUtils.defaultObject(clinicalAnalysis.getInterpretations(), ArrayList::new)); clinicalAnalysis.setPriority(ParamUtils.defaultObject(clinicalAnalysis.getPriority(), ClinicalAnalysis.Priority.MEDIUM)); clinicalAnalysis.setUuid(UUIDUtils.generateOpenCGAUUID(UUIDUtils.Entity.CLINICAL)); QueryResult<ClinicalAnalysis> queryResult = clinicalDBAdaptor.insert(study.getUid(), clinicalAnalysis, options); return queryResult; }
@Test public void updateSubjectsAndFamilyTest() throws CatalogException { createDummyEnvironment(false); ObjectMap params = new ObjectMap() .append(ClinicalAnalysisDBAdaptor.QueryParams.PROBAND.key(), new Individual().setId("child1").setSamples(Arrays.asList(new Sample().setId("sample2")))) .append(ClinicalAnalysisDBAdaptor.QueryParams.FAMILY.key(), new Family().setId("family")); QueryResult<ClinicalAnalysis> updateResult = catalogManager.getClinicalAnalysisManager().update(STUDY, "analysis", params, QueryOptions.empty(), sessionIdUser); assertEquals(1, updateResult.getNumResults()); assertEquals(0, updateResult.first().getInterpretations().size()); assertEquals(catalogManager.getFamilyManager().getUid("family", STUDY, sessionIdUser).getResource().getUid(), updateResult.first().getFamily().getUid()); assertEquals(catalogManager.getIndividualManager().getUid("child1", STUDY, sessionIdUser).getResource().getUid(), updateResult.first().getProband().getUid()); assertEquals(1, updateResult.first().getProband().getSamples().size()); assertEquals(catalogManager.getSampleManager().getUid("sample2", STUDY, sessionIdUser).getResource().getUid(), updateResult.first().getProband().getSamples().get(0).getUid()); }